Show HN: A template to help you write your web project specs in less than 10mins https://ift.tt/2I6yFbK

Show HN: A template to help you write your web project specs in less than 10mins https://ift.tt/2VpPjLD February 28, 2020 at 07:14AM

Liked on YouTube: شاهد ماذا يفعل الثعبان عندما يحاصر في دائرة من الملح؟ سبحان الله !!

شاهد ماذا يفعل الثعبان عندما يحاصر في دائرة من الملح؟ سبحان الله !!

شاهد ماذا يفعل الثعبان عندما يحاصر في دائرة من الملح؟ سبحان الله .. دعونا نواجه الحقيقة، الثعابين ليست حيوانات لطيفه نحبها. الثعابين هي الزواحف التى يمكن مصادفتها بشكل عام في التربة والمياه. هناك الكثير لا سيما أولئك الذين يقومون بأعمال البستنة في مزارع الكروم يجربون طرقًا مختلفة للتخلص من الثعابين. حسنا ما هي تلك الطرق؟! تابعوا معنا فيديو اليوم لتتعرفوا عليها. ---------------------------------------------------------------------------------------------- ● وسع معرفتك وإكتشف أسرار عالمك مع قناة (حقائق وأسرار) هي قناة تقدم فيديوهات ثقافية وترفيهية في مختلف المواضيع والمجالات الآتية معلومات, حقائق, غموض, ترفيه, أسرار, أغرب, أفضل, هل تعلم, أشياء لا تعرفها, أكثر, أحداث غريبة, علوم, توب 10, الظواهر الغامضة, كل هذا وأكثر سوف ترونه في مقاطع يومية على قناة حقائق وأسرار. يتم إعداد فيديوهاتنا بناءًا على عمليات بحث وتجميع للمعلومات من مصادر موثوقة. نتمنى أن تستمتعوا بوجودكم معنا :) ~ أشترك في مجموعة قنواتنا المختلفة: ● القناة الرئيسية "حقائق وأسرار": https://www.youtube.com/channel/UCBzrJ1zGf9-0cd5-n7sBraQ ● قناتنا الثانية "حقائق وأسرار 2": https://www.youtube.com/channel/UCj2xJxAiCnBV8-pglxCq-Gg ● حقائق وأسرار - ألغاز: https://www.youtube.com/channel/UCJ3HOKyjMsenZgEwG9kqmYA ● حقائق وأسرار - رياضة: https://www.youtube.com/channel/UCFfVulOGna1qPfVYjiK0rTg ~ تابعونا على وسائل التواصل الإجتماعي: ● فيس بوك: https://ift.tt/2cb8did ● تويتر: https://twitter.com/facts806 ---------------------------------------------------------------------------------------------- For Business or copyright matters please contact us at: (للتواصل والإعلان) jasonjack806@gmail.com ---------------------------------------------------------------------------------------------- ★ إذا أعجبك الفيديو لا تنسى الإعجاب به وللمزيد أشترك في قناة حقائق وأسرار ★
via YouTube https://youtu.be/KON17YxXWsM

Liked on YouTube: المساء | الرئيس الجزائري في أول زيارة له للسعودية

المساء | الرئيس الجزائري في أول زيارة له للسعودية

في أول زيارة له، منذ انتخابه في ديسمبر الماضي، وصل الرئيس الجزائري عبد المجيد تبون إلى السعودية، حيث يجري مباحثات مع القيادة في المملكة حول العديد من الملفات وعلى رأسها الأزمة الليبية. أزمة تسعى الجزائر للمشاركة في إيجاد حل لها وحشد التأييد اللازم لعقد قمة تستضيفها لهذا الغرض. https://ift.tt/29uwJ9S https://ift.tt/12AN86k https://twitter.com/skynewsarabia https://ift.tt/2Nhv0LX
via YouTube https://youtu.be/Hmu2Eb4-vx8

Liked on YouTube: بالخيول مراسم الاستقبال التاريخي التي أجري الرئيس تبون في الديوان الملكي السعودي لن تصدق

بالخيول مراسم الاستقبال التاريخي التي أجري الرئيس تبون في الديوان الملكي السعودي لن تصدق

via YouTube https://youtu.be/lF0eAWUS-bs

Show HN: Run your GitHub Actions locally https://ift.tt/2I18e7v

Show HN: Run your GitHub Actions locally https://ift.tt/2tKTin1 February 28, 2020 at 02:25AM

شاهد ماذا يفعل الثعبان عندما يحاصر في دائرة من الملح؟ سبحان الله !!

المساء | الرئيس الجزائري في أول زيارة له للسعودية

بالخيول مراسم الاستقبال التاريخي التي أجري الرئيس تبون في الديوان الملكي السعودي لن تصدق

Muni's Unsung Heroes of Black History

Muni's Unsung Heroes of Black History
By Jeremy Menzies

Black History Month is a great opportunity to tell big important stories, but also to highlight the smaller, less noted stories of everyday people. This week, we're looking back through Muni history at a few people whose day-to-day achievements may not have made headlines but whose contributions nonetheless made a difference to breaking down racial barriers in San Francisco's transit industry.

In September 1950, Muni started the "Courtesy Citation" program to honor the hard work of Muni operators. Operators who received commendations from the public would be recognized in the railway's newsletter and entered into the running for "Muni Man of the Month", an award that brought greater recognition in the form of a $50 check and a special card featuring the winner's photo inside Muni vehicles.

Lilburn Delaney, conductor on the H Potrero streetcar, leans out the back platform of a car in this 1948 photo.

Right away, nominations came in for many black Municipal Railway transit operators who were recognized by riders for their excellent public service. Lilburn Delaney became the first African-American man to be given the honor of "Muni Man" in February 1951. Delaney started at Muni in September 1945 as a conductor on the H Potrero streetcar line and at the time of his award, was a trolley coach operator on the 5 McAllister.

Reginald Simpkins poses for a portrait at the Muni Photo Lab in this 1951 shot. Winners of the Muni Man award like Simpkins were honored with a $50 check and advertisements featuring their photo inside Muni vehicles.

Several months after Delaney, Reginald H. Simpkins was honored as top operator in September of that year. Simpkins, a driver on the 43 Roosevelt bus route, had no shortage of praise from riders on his bus. One letter noted how Simpkins "never loses his dignity or efficiency..." even during busy and stressful rush hour runs and "his sense of humor is so outstanding that it is a real pleasure to ride on his bus."

Beverly Hopkins (Right) and Helen Carson make repairs to a bus at Woods Division.

In June 1978, Beverly Hopkins became one of the first black women to join the maintenance crew at Woods Division. By the time of Beverly’s hiring in the late 1970s, the Muni staff newsletter says the eight newly hired women comprised the “largest number of female automotive service persons ever to work for Muni shops. The need was there and they were qualified.”

Evelyn Wells, Muni's first female Inspector poses while at work in the field in this 1979 shot.

Evelyn J. Wells holds the honor of being the first African American woman to be appointed as a Muni inspector (badge #54). As an inspector, she was responsible for supervising service, helping investigate accidents, and clearing up delays on bus and rail lines. Working previously as an N Judah operator, Wells began as an inspector in May 1979 at age 28.

These brief highlights barely begin to tell the full story of the contributions or struggles of people of color in San Francisco's public transit history. While much focus goes to major figures and big breakthroughs in history, the day in day out work of these "unsung heroes" went a long way to break down racial barriers within the industry.

Published February 27, 2020 at 10:02PM
https://ift.tt/2TpFkmI

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Show HN: Breezy – A Marketplace for Easily Finding the Best Pet Insurance https://ift.tt/2vkDfjW

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Launch HN: Probably Genetic (YC W19): At-home DNA testing for every gene https://ift.tt/2To37Ds

Launch HN: Probably Genetic (YC W19): At-home DNA testing for every gene Hi Hacker News, We’re Harley and Lukas from Probably Genetic ( https://ift.tt/2qqG7t6 ). We built an at-home physician-ordered DNA test that covers all genes and looks for pathogenic variants related to thousands of rare genetic conditions. Why rare genetic conditions? It may seem like a niche problem but there are ~400 million people worldwide with a rare genetic condition, half of which are currently undiagnosed. To put this into perspective, it’s estimated that 1 in 10 Americans has a rare condition and while each of the individual ~10,000 conditions is rare, the population that suffers such conditions is larger than cancer and HIV combined. Furthermore, for the patients that have been diagnosed, it takes on average 8 years for doctors to identify their conditions. You’ve already heard of rare genetic conditions, you might just not be aware of it. Remember the Ice Bucket Challenge for ALS? Most of these diseases initially look like more common conditions, such as autism, chronic pain, ADHD, or even the flu, before patients get worse. This diagnostic odyssey can be extremely costly for patients and in our experience, some are spending more than $30,000 and seeing more than 10 doctors before they get access to the right specialists and testing. We have seen this problem first-hand. Lukas is a rare-disease expert and worked on the world’s largest rare disease project (the 100,000 genomes project) as a PhD candidate at Oxford University in the UK. I am trained as a theoretical computational astrophysicist and during my PhD and fellowship at Cambridge University and Oxford University, I spent my spare time working with National Healthcare Service doctors developing and publishing medical diagnostics with machine learning. Our original idea was actually slightly different from what we have now. We spent a lot of effort on developing a symptom checker specifically for rare conditions with the idea to comb through existing medical records and flag patients with potential rare genetic conditions because, unsurprisingly, WebMD and others aren't really great for this purpose. As we were building this, we realized that for the patients we worked with, even if their symptoms were suggestive of a genetic condition, access to clinical-grade genetic testing was extremely difficult for many as it was either too expensive because insurance wouldn’t cover the cost, or they couldn’t find a doctor that would order it. Thus, we decided to use our expertise to both find these patients more efficiently and built up a service to drastically reduce the time and cost to access clinical-grade genetic testing. About the test: Just like most DNA tests, you can do this from home and it’s noninvasive, all we need is a little saliva. Unlike most DNA tests, ours is physician-ordered, sequenced in a CLIA-accredited and CAP-certified lab, the results are signed out by a licensed clinical lab director, all users have access to genetic counseling, and we try to incorporate as much phenotypic data as possible into the analysis. Our product is a whole-exome sequencing test with 100x coverage and covers all of the more than 20,000 genes, where 85% of known disease-causing variants occur. People always ask, how are you different from 23andme? Looking for a rare genetic condition is kind of like trying to find a typo in a novel. Using a 23andme (or similar) test to look for such a condition is like trying to find a typo in the first Harry Potter novel and stopping after 75 words. Those tests are just not meant for this purpose. Most are based on genotyping arrays that look for very specific variants at predetermined locations in the genome. However, the variants that cause rare diseases can occur anywhere. For example, there are over 1,700 different mutations in the CFTR gene that can cause cystic fibrosis. Approximately 85% of the known pathogenic mutations occur in the protein-coding regions of DNA called the exome. Our test is a whole exome sequencing test rather than a genotyping array, which allows us to cover all of the genes in a person’s DNA. We often get the question, why not do whole genome rather than whole exome? Right now it simply comes down to accessibility. For most consumers, whole genome sequencing is still too expensive and the additional gain in terms of coverage of pathogenic mutations doesn’t necessarily warrant the significant price increase. That being said, if you are interested in clinical-grade whole genome sequencing, we can soon offer this as well. Patient privacy is a huge concern for us and something we think about all the time. Quite simply, we will never share any of our users' data without explicit consent and we are more than happy to both delete our users' data and destroy their sample if requested. Interestingly, we often have the opposite problem where we receive inbound requests of people trying to share their data with us to see if we can help them. Out of the more than 10,000 rare diseases, over 95% do not have an FDA-approved treatment, which is why the rare disease community is so motivated to leverage their personal insights. We have started a waitlist to provide such services and are actively seeking ways to help these people and integrate them into our community, even if they have not had sequencing through us. Finally, how much does it cost? A single test right now costs $899 on our website, but we try to offer the test in trios where we sequence both the patient and two family members as this often gives a higher diagnostic yield. The latter option is $1,799. We expect that the test price will decrease significantly with time as the cost of sequencing drops and more of the analysis can be automated. We don’t currently accept insurance; however, in our experience, using more traditional channels to access this kind of testing can result in bills of >$10,000, not all of which may be covered. Many insurance providers don’t even cover this kind of testing, except for very specific purposes, despite more and more of the medical literature recommending exome sequencing as a first-tier diagnostic for specific indications. Ideally, we would make the product so affordable that it simply makes sense to use us rather than billing insurance for the test plus the numerous doctor and specialist visits needed before and after it’s ordered. We are currently offering the test at cost, as we aim not to profit off of the patients that need it most, and this is sustainable because, with the consent of the patients, we can leverage our data asset for drug discovery, clinical trial recruitment, and drug repurposing. Consumer genetic testing is growing rapidly as an industry and nearly doubling every single year. What is missing from this market is accessible physician-ordered testing that can genuinely help those with complex symptoms and undiagnosed genetic conditions. This is what we hope to provide. If you have any questions or feedback, we would love to hear it and please check us out at https://ift.tt/2qqG7t6 . February 27, 2020 at 07:17PM

Show HN: Pep – Turn Your Website into a Progressive Web App https://ift.tt/2I3pWXT

Show HN: Pep – Turn Your Website into a Progressive Web App https://pep.dev/ February 27, 2020 at 07:02PM

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Show HN: Twitter lists for YC 2017, YC 2018, YC 2019 companies https://ift.tt/3c6muto

Show HN: Twitter lists for YC 2017, YC 2018, YC 2019 companies These are all participating founders. It is a great way to learn what they are all up to now: * YC S2017 https://twitter.com/i/lists/1230735563034021893 * YC W2017 https://twitter.com/i/lists/1230735739861618691 * YC S2018 https://twitter.com/i/lists/1230734925881470976 * YC W2018 https://twitter.com/i/lists/1230735246502424577 * YC S2019 https://twitter.com/i/lists/1230728767556833280 * YC W2019 https://twitter.com/i/lists/1230734559743922178 Also: * YC S2020 https://twitter.com/i/lists/1230850014617862145 (will be populated in the future) * YC W2020 https://twitter.com/i/lists/1230849940101844999 (will be populated in the future) February 27, 2020 at 01:34PM

Show HN: Metomic Contextual Consent – a privacy layer under embedded content https://ift.tt/2I2HNyq

Show HN: Metomic Contextual Consent – a privacy layer under embedded content https://ift.tt/3cd3MQZ February 27, 2020 at 11:54AM